In 1886, a Welsh cyclist is popularly reputed to have died after drinking a blend of cocaine, caffeine and strychnine, supposedly in the Bordeaux–Paris race.

When necessity demands medical treatment with any substance which, because of its nature, dosage, or application is able to boost the athlete's performance in competition in an artificial and unfair manner, this too is regarded as doping.'

'The administration of or use by a competing athlete of any substance foreign to the body or any physiologic substance taken in abnormal quantity or taken by an abnormal route of entry into the body with the sole intention of increasing in an artificial and unfair manner his/her performance in competition. The International Olympic Committee slightly modified this, and adopted this definition: 'Doping is the administration to a normal subject in any possible way of a foreign agent or abnormal quantities of physiological substances with the sole purpose of increasing artificially and in an unfair manner the performance of the subject participating in a contest.' In 1963, the Council of Europe gave the following definition of doping: It also contains and clarifies cases where subsequent evidence and explanation has shown the parties to be innocent of illegal practice. Thus the list contains doping incidents, those who have tested positive for illegal performance-enhancing drugs, prohibited recreational drugs or have been suspended by a sports governing body for failure to submit to mandatory drug testing. The following is an incomplete list of doping cases and recurring accusations of doping in professional cycling, where doping means 'use of physiological substances or abnormal method to obtain an artificial increase of performance.' It is neither a list of shame nor a list of illegality, as the first laws were not passed until 1965 and their implementation is an ongoing developing process.

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